Ki-67 labeling index and Knosp classification of pituitary adenomas

The classification of pituitary tumors is frequently updated to optimize guidance for clinical treatment based on current knowledge. To date, the World Health Organization conducts periodic expert review consensus meetings and publishes results. These include recommendations behavior more aggressive, high Ki-67 index (>3%)pituitary. A Knosp grade (>3) associated with a risk recurrence. We report an inverse relationship between labeling functional adenomas nonfunctional adenoma (Spearman correlation coefficient in r= ?0.59, p < .001 n = 75 r 0.367, .01 168 adenoma), suggest that this results from early diagnosis before they become aggressive recurrent. There were few articles analyzing adenomas.Our study showed negatively correlated positive adenomas.